Aurora-A — A guardian of poles

@article{Marumoto2005AuroraAA,
  title={Aurora-A — A guardian of poles},
  author={Tomotoshi Marumoto and Dongwei Zhang and Hideyuki Saya},
  journal={Nature Reviews Cancer},
  year={2005},
  volume={5},
  pages={42-50}
}
Key PointsAurora/Ipl1-related kinases are evolutionally conserved serine/threonine kinases that regulate mitotic progression in various organisms. Humans have three classes of Aurora kinases (A, B and C). Aurora-A and -B are ubiquitously expressed and regulate cell-cycle events from G2 to M phase.Aurora-A is localized at centrosome during interphase, translocated to mitotic spindles in early mitotic phase and degraded after metaphase–anaphase transition. Activation of Aurora-A is required for… CONTINUE READING

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