Aurora-A — A guardian of poles

@article{Marumoto2005AuroraAA,
  title={Aurora-A — A guardian of poles},
  author={T. Marumoto and Dongwei Zhang and H. Saya},
  journal={Nature Reviews Cancer},
  year={2005},
  volume={5},
  pages={42-50}
}
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in… Expand
RACK1 affects the progress of G2/M by regulating Aurora-A
The Aurora-A/TPX2 complex: a novel oncogenic holoenzyme?
Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis
Aurora kinases as an anti-cancer target.
Pak GITs to Aurora-A.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 103 REFERENCES
Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells
Mitotic mechanics: the auroras come into view.
Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells*
...
1
2
3
4
5
...