Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells.

@article{Guan2007AuroraAAN,
  title={Aurora-A, a negative prognostic marker, increases migration and decreases radiosensitivity in cancer cells.},
  author={Zhong Guan and Xian-ren Wang and Xiaofeng Zhu and Xue-fei Huang and Jie Xu and Li-hui Wang and Xiang-bo Wan and Zi-jie Long and Jian-nan Liu and Gong-kan Feng and Wenlin Huang and Yi-xin Zeng and Fu-jin Chen and Quentin Liu},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={10436-44}
}
Centrosomal Aurora-A (Aur-A) kinase ensures proper spindle assembly and accurate chromosome segregation in mitosis. Overexpression of Aur-A leads to centrosome amplification, aberrant spindle, and consequent genetic instability. In the present study, Aur-A was found to be overexpressed in laryngeal squamous cell carcinoma (LSCC). Moreover, Aur-A expression was adversely correlated with median survival, and further identified as a potential independent factor for disease prognosis. Suppression… CONTINUE READING

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