Aurora A, Meiosis and Mitosis

  title={Aurora A, Meiosis and Mitosis},
  author={Richard F Crane and Bedrick B. Gadea and Laurie E. Littlepage and Hua Wu and Joan V. Ruderman},
  journal={Biology of the Cell},
The functional diversity of Aurora kinases: a comprehensive review
Understanding the functional interplay of Aurora kinases in various types of human cells, including tumor cells, could help to evaluate their relevance as potential therapeutic targets in cancer.
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest
It is shown that a previously undescribed E3 ligase component belonging to the SCF (Skp-Cullin1-F-box protein) E3ligase family, SCFFBXL7, impairs cell proliferation by mediating Aurora A polyubiquitination and degradation.
A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.
Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extracts.
Results show that Aurora kinase activity is required to ensure the maintenance of condensed chromosomes, the generation of chromosome-induced spindle microtubules, and activation of the spindle integrity checkpoint.
Aurora kinase‐A regulates microtubule organizing center (MTOC) localization, chromosome dynamics, and histone‐H3 phosphorylation in mouse oocytes
As a predominant isoform among Aurks in oocytes, AurkA plays critical roles in mouse oocyte meiosis by regulating spindle and chromosome dynamics.
Aurora C is directly associated with Survivin and required for cytokinesis
Use of sensitive RT‐PCR to amplify the C‐terminal of Aurora C found that Aurora C is not only expressed highly in testis, but also among 16 other human tissues in a broad‐spectrum way, demonstrating that the member of the chromosomal passenger complex is required for cytokinesis.
Phosphorylation of MAP65-1 by Arabidopsis Aurora Kinases Is Required for Efficient Cell Cycle Progression1[OPEN]
Arabidopsis Aurora kinases phosphorylate MAP65-1 at its unfolded tail domain and dynamic switching of its phosphorylation status throughout mitosis is required for proper cell cycle progression
Aurora A Kinase Function at Kinetochores.
  • J. DeLuca
  • Biology
    Cold Spring Harbor symposia on quantitative biology
  • 2017
Although Aurora B is regarded as the "master regulator" of kinetochore-microtubule attachment, it is becoming clear that this kinase is not solely responsible for phosphorylating Hec1 and other kinetchore substrates to facilitate microtubule turnover.
Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells.
The results indicate that already in initial stages of cancer progression Aurora-A overexpression could have a major role in inducing supernumerary centrosomes and aneuploidy, as shown by immunohistochemistry on tissue sections from various stages of human colon cancer.


On the role of aurora-A in centrosome function
This review focuses on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1, indicating that the kinase is an oncogene.
Involvement of Aurora A Kinase during Meiosis I-II Transition inXenopus Oocytes*
It is concluded that Aurora A and Eg5 are involved in meiosis I to meiosis II transition in Xenopus oocytes.
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
It is shown that BubR1 is not only required for spindle checkpoint function, but is also required for chromosome alignment, which suggests that by targeting checkpoint proteins to kinetochores, Aurora B couples chromosome alignment with anaphase onset.
Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells
This work has shown that aurora‐A is a mammalian counterpart of aurora/Ipl1‐related kinases and is thought to be a potential oncogene, and the regulation of Aurora‐A activation and the commitment in the progression of G2‐M phase are largely unknown in mammalian cells.
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.
Results suggest that dephosphorylation of serine 53 during mitotic exit could control the timing of Aur-A destruction, allowing recognition of both the A box and D box by Cdh1-activated APC/C.
Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle.
These studies contrast the relative cellular dynamics of Aurora-A with other cytoskeletal proteins that share its micro-domains, and identify essential regions required for targeting and dynamics.
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.