Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

  title={Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation},
  author={Hidemasa Goto and Yoshihiro Yasui and Erich A. Nigg and Masaki Inagaki},
  journal={Genes to Cells},
Background:  Histone H3 (H3) phosphorylation plays important roles in mitotic chromosome condensation. We reported that H3 phosphorylation occurs at Ser28, as well as at Ser10 during mitosis, at least in mammals. Aurora B was recently demonstrated to be responsible for Ser10 phosphorylation in S. cerevisiae, C. elegans, Drosophila and Xenopus egg extract. 

CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation

The phosphorylation of histone H2B at serine 6 (H2B S6ph) is discovered as a new chromatin modification site and it is found that this modification occurs during the early mitotic phases at inner centromeres and pericentromeric heterochromatin.

Neither Aurora B Activity nor Histone H3 Phosphorylation Is Essential for Chromosome Condensation During Meiotic Maturation of Porcine Oocytes1

It is suggested that AURKB activity and Ser-10 phosphorylation of histone H3 are not required for chromosome condensation in pig oocytes, but might be required for further processing of chromosomes during meiosis.

Epigenetic countermarks in mitotic chromosome condensation

These data provide further evidence for a role of mitotic histone H3 phosphorylation in blocking transcriptional programs or preserving the ‘memory’ PTMs and show that H3 phosphate serves as an integral step in the condensation of chromosome arms.

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

It is demonstrated that AURKB localizes to the telomeres in mouse embryonic stem cells, where it interacts with the essential telomere protein TERF1.

Role of histone modification in chromatin dynamics.

This review discusses recent progress in studies of histone phosphorylation and discusses the role of acetylation and methylation in dynamic condensation/relaxation that occurs during the cell cycle.

Haspin: A Mitotic Histone Kinase Required for Metaphase Chromosome Alignment

Possible mechanisms of haspin action and the function of histonephosphorylation in mitosis are discussed and some of the questions raised are outlined, including what role haspin might play in cancer.

The cellular geography of Aurora kinases

Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the interactions between these two at the kinetochore during mitosis and regulate signalling by the spindle-assembly checkpoint pathway and cytokinesis.

Aurora B kinase is required for cytokinesis through effecting spindle structure

It is thought that Aurora B may not only play a role as kinase, but regulate microtubule plus ends as mitosis progresses, including both kinetochore and polar microtubules.



Histone H3 phosphorylation and cell division

A novel hypothesis, termed the ‘ready production label’ model, explains the results in the literature and suggests that phosphorylation of histone H3 is a part of a complex signaling mechanism.

Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

It is shown that depleting Aurora B kinase using double-stranded RNA interference in cultured Drosophila cells results in polyploidy, and conserved functions of Aurora B Kinase in chromosome transmission and cytokinesis are discussed.

Chromosomal passengers and the (aurora) ABCs of mitosis.

Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation.

Observations suggest that H3 phosphorylation is required for cell cycle progression and specifically for the changes in chromatin structure incurred during chromosome condensation.

Identification of a Novel Phosphorylation Site on Histone H3 Coupled with Mitotic Chromosome Condensation*

Observations suggest that H3 phosphorylation at Ser28, together with Ser10, is a conserved event and is likely to be involved in mitotic chromosome condensation.

Chromatin-associated Protein Phosphatase 1 Regulates Aurora-B and Histone H3 Phosphorylation*

It is found that stimulation of histone H3 phosphorylation in interphase cytosol does not drive chromosome condensation or targeting of 13 S condensin to chromatin, and is inhibited directly in inter phase chromatin by PP1.