Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP.

Abstract

Aurintricarboxylic acid (ATA) is a potent inhibitor of many enzymes needed for cell and virus replication, such as polymerases, helicases, nucleases, and topoisomerases. This study examines how ATA interacts with the helicase encoded by the hepatitis C virus (HCV) and reveals that ATA interferes with both nucleic acid and ATP binding to the enzyme. We show… (More)
DOI: 10.1021/bi4006495

Topics

8 Figures and Tables

Cite this paper

@article{Shadrick2013AurintricarboxylicAM, title={Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP.}, author={William R. Shadrick and Sourav Mukherjee and Alicia M. Hanson and Noreena L. Sweeney and David N. Frick}, journal={Biochemistry}, year={2013}, volume={52 36}, pages={6151-9} }