Auricular chondritis in NOD.DQ8.Abetao (Ag7-/-) transgenic mice resembles human relapsing polychondritis.

@article{Taneja2003AuricularCI,
  title={Auricular chondritis in NOD.DQ8.Abetao (Ag7-/-) transgenic mice resembles human relapsing polychondritis.},
  author={Veena Taneja and Mark D. Griffiths and Marshall D. Behrens and Harvinder S. Luthra and Chella S. David},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 12},
  pages={
          1843-50
        }
}
Relapsing polychondritis is a multisystem autoimmune disease involving cartilage destruction but no known causative antigen. HLA-DQ8 has been associated with various autoimmune diseases in humans. To study the role of DQ8 in autoimmune diseases, we have generated transgenic mice expressing DQ8 (DQA1*0301, DQB1*0302) in a NOD background lacking endogenous class II molecules (Abetao). Upon immunization with type II collagen (CII), 85% of NOD.DQ8 mice develop severe experimental polychondritis… CONTINUE READING

Citations

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Relapsing polychondritis.

  • Joint, bone, spine : revue du rhumatisme
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André Cavalcanti, Cassia Maria Passarelli Lupoli Barbosa, Claudio Arnaldo Len, Maria Teresa R. A. Terreri, Maria Odete Esteves Hilário
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