Corpus ID: 19903639

Auranofin inhibits the induction of interleukin 1 beta and tumor necrosis factor alpha mRNA in macrophages.

@article{Bondeson1995AuranofinIT,
  title={Auranofin inhibits the induction of interleukin 1 beta and tumor necrosis factor alpha mRNA in macrophages.},
  author={J. Bondeson and R. Sundler},
  journal={Biochemical pharmacology},
  year={1995},
  volume={50 11},
  pages={
          1753-9
        }
}
  • J. Bondeson, R. Sundler
  • Published 1995
  • Medicine
  • Biochemical pharmacology
  • Gold compounds are widely used in the treatment of rheumatoid arthritis, but their mechanisms of action remain unclear. We demonstrate here that auranofin (AF) (0.1-3 microM), but neither the hydrophilic gold compounds aurothiomalate (ATM) and aurothioglucose nor methotrexate or D-penicillamine, inhibits the induction of interleukin 1 beta and tumor necrosis factor (TNF) alpha mRNA and protein by either zymosan, lipopolysaccharide (LPS), or various bacteria in mouse macrophages. The auranofin… CONTINUE READING
    9 Citations
    The anti‐inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species
    • 135
    Auranofin, as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4.
    • 65
    Gene expression profiling of macrophages: implications for an immunosuppressive effect of dissolucytotic gold ions
    • 6
    • PDF