Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au–Se adduct

@article{JacksonRosario2009AuranofinDS,
  title={Auranofin disrupts selenium metabolism in Clostridium difficile by forming a stable Au–Se adduct},
  author={Sarah Elizabeth Jackson-Rosario and Darin M. Cowart and A. Myers and Rebecca J. Tarrien and Rodney L Levine and Robert Scott and William Thomas Self},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2009},
  volume={14},
  pages={507-519}
}
Clostridium difficile is a nosocomial pathogen whose incidence and importance are on the rise. Previous work in our laboratory characterized the central role of selenoenzyme-dependent Stickland reactions in C. difficile metabolism. In this work we have identified, using mass spectrometry, a stable complex formed upon reaction of auranofin (a gold-containing drug) with selenide in vitro. X-ray absorption spectroscopy supports the structure that we proposed on the basis of mass-spectrometric data… CONTINUE READING