Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome

@article{Newman2010AuranofinPA,
  title={Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome},
  author={Zachary L. Newman and Nicole Sirianni and Christina Mawhinney and Margaret S. Lee and Stephen H Leppla and Mahtab Moayeri and Lisa M. Johansen},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2010},
  volume={55},
  pages={1028 - 1035}
}
ABSTRACT Anthrax lethal toxin (LT) is the major virulence factor for Bacillus anthracis. The lethal factor (LF) component of this bipartite toxin is a protease which, when transported into the cellular cytoplasm, cleaves mitogen-activated protein kinase kinase (MEK) family proteins and induces rapid toxicity in mouse macrophages through activation of the Nlrp1b inflammasome. A high-throughput screen was performed to identify synergistic LT-inhibitory drug combinations from within a library of… Expand
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