Auranofin, a gold(I)-containing antirheumatic compound, activates Keap1/Nrf2 signaling via Rac1/iNOS signal and mitogen-activated protein kinase activation.

@article{Kim2010AuranofinAG,
  title={Auranofin, a gold(I)-containing antirheumatic compound, activates Keap1/Nrf2 signaling via Rac1/iNOS signal and mitogen-activated protein kinase activation.},
  author={Nam-Hoon Kim and Mi-Kyung Oh and Hyo Jung Park and In-Sook Kim},
  journal={Journal of pharmacological sciences},
  year={2010},
  volume={113 3},
  pages={
          246-54
        }
}
Auranofin (2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-[triethylphosphine] gold) is a gold(I)-containing antirheumatic drug that possesses anti-inflammatory properties. The pharmacological activity of this drug is associated with its ability to induce heme oxygenase-1 (HO-1). However, the mechanism underlying auranofin-mediated HO-1 induction remains unclear. We investigated the action of auranofin on activation of nuclear factor erythroid 2-related factor 2 (Nrf2), an activator of… CONTINUE READING

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