The article "Wie sollen wir uns zu der homöopathie stellen?" ("What attitude should we have towards homeopathy?") by August Bier published in the Münchener Medizinische Wochenschrift in 1925 led to a considerable number of contributions concerning the effectiveness or ineffectiveness of homeopathy in the leading German medical journals. The crisis of medicine in the 1920s as well as Bier's position as a famous surgeon paved the way for a new interest in homeopathy as a holistic medical concept. Central issues in this debate between homeopaths and allopaths were the potentisation (often misunderstood as a mere process of dilution), the law of similars and the proving of remedies on healthy subjects. The analysis of this debate shows that most of the arguments used in 1925 resemble those of the 21st century in a surprising way.