Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study.

  title={Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study.},
  author={Jimmi Nielsen and Charlotte Emborg and Susanne Gydesen and Jesper Dybbro and J\orgen Aagaard and Karsten Haderup and Pia Glyngdal and Susanne Fabricius and Dorrit Thode and Henrik Lublin and Torben Andersen and Per Damkier and David McDonald Taylor},
  journal={Journal of clinical psychopharmacology},
  volume={32 2},
Clozapine augmentation with antipsychotic drugs is widely used despite sparse evidence supporting this strategy. Sertindole is a nonsedating atypical antipsychotic drug with low affinity for cholinergic receptors, which makes it potentially suitable for augmentation of clozapine. The study design was a 12-week, double-blind, randomized, placebo-controlled study including patients with International Statistical Classification of Diseases, 10th Revision schizophrenia (F20.0-F20.3) and treated… CONTINUE READING


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