Augmenting antitumor T-cell responses to mimotope vaccination by boosting with native tumor antigens.

@article{Buhrman2013AugmentingAT,
  title={Augmenting antitumor T-cell responses to mimotope vaccination by boosting with native tumor antigens.},
  author={Jonathan D. Buhrman and Kimberly R Jordan and Lance U'ren and Jonathan Sprague and Charles B. Kemmler and Jill E Slansky},
  journal={Cancer research},
  year={2013},
  volume={73 1},
  pages={74-85}
}
Vaccination with antigens expressed by tumors is one strategy for stimulating enhanced T-cell responses against tumors. However, these peptide vaccines rarely result in efficient expansion of tumor-specific T cells or responses that protect against tumor growth. Mimotopes, or peptide mimics of tumor antigens, elicit increased numbers of T cells that crossreact with the native tumor antigen, resulting in potent antitumor responses. Unfortunately, mimotopes may also elicit cells that do not… CONTINUE READING
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