Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

  title={Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice},
  author={G. Stanley Howell and Hernando Gomez and Richard D. Collage and Patricia Loughran and Xiang-hong Zhang and Daniel A. Escobar and Timothy R Billiar and Brian S Zuckerbraun and Matthew Randall Rosengart},
  booktitle={PloS one},
OBJECTIVE To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery in aged mice. DESIGN Murine model of endotoxemia and cecal ligation and puncture (CLP) induced acute kidney injury (AKI). SETTING Academic research laboratory. SUBJECTS C57Bl/6 mice of 8 (young… CONTINUE READING
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