Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents

@inproceedings{Hninger2015AugmentingAI,
  title={Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents},
  author={Erika H{\'e}ninger and Timothy E. G. Krueger and Joshua Michael Lang},
  booktitle={Front. Immunol.},
  year={2015}
}
Epigenetic silencing of immune-related genes is a striking feature of the cancer genome that occurs in the process of tumorigenesis. This phenomena impacts antigen processing and antigen presentation by tumor cells and facilitates evasion of immunosurveillance. Further modulation of the tumor microenvironment by altered expression of immunosuppressive cytokines impairs antigen-presenting cells and cytolytic T-cell function. The potential reversal of immunosuppression by epigenetic modulation is… CONTINUE READING
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