Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis

@inproceedings{Bailey2017AugmentedTC,
  title={Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis},
  author={Liane Jennifer Bailey and Sruthi Alahari and Andrea C Tagliaferro and Martin Post and Isabella Caniggia},
  booktitle={Cell death & disease},
  year={2017}
}
Preeclampsia, a serious hypertensive disorder of pregnancy, is characterized by elevated ceramide (CER) content that is responsible for heightened trophoblast cell death rates via apoptosis and autophagy. Whether trophoblast cells undergo necroptosis, a newly characterized form of regulated necrosis, and the potential role of CER in this process remain to be established. Herein, we report that exposure of both JEG3 cells and primary isolated cytotrophoblasts to C16:0 CER in conjunction with a… CONTINUE READING