Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid.

@article{Zhang2006AugmentedSO,
  title={Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid.},
  author={Hai-Tao Zhang and Yongzhen Wu and Barbara Malewicz and Junxuan Lu and Song Li and James E. Marshall and Clement Ip and Yan Dong},
  journal={Cancer},
  year={2006},
  volume={107 12},
  pages={2942-8}
}
BACKGROUND Previous reports showed that alpha-tocopheryl succinate (alphaTS) and methylseleninic acid (MSA) independently reduce the abundance of androgen receptor (AR) in prostate cancer cells. The response to MSA happens quickly, whereas the response to alphaTS takes much longer. The present study was designed to investigate whether a combination of… CONTINUE READING