Augmented sparse reconstruction of protein signaling networks.

  title={Augmented sparse reconstruction of protein signaling networks.},
  author={Domenico Napoletani and Tobias Sauer and Daniele C. Struppa and Emanuel Petricoin and Lance D Liotta},
  journal={Journal of theoretical biology},
  volume={255 1},
The problem of reconstructing and identifying intracellular protein signaling and biochemical networks is of critical importance in biology. We propose a mathematical approach called augmented sparse reconstruction for the identification of links among nodes of ordinary differential equation (ODE) networks, given a small set of observed trajectories with various initial conditions. As a test case, the method is applied to the epidermal growth factor receptor (EGFR) driven signaling cascade, a… CONTINUE READING
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