Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption

@article{Walters2003AugmentedRT,
  title={Augmented responses to morphine and cocaine in mice with a 12-lipoxygenase gene disruption},
  author={Carrie L. Walters and Bao-cheng Wang and Murrell Godfrey and Deming Sun and Colin D. Funk and Julie A. Blendy},
  journal={Psychopharmacology},
  year={2003},
  volume={170},
  pages={124-131}
}
RationaleRecent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, although the functional significance of these effects in vivo are not known.ObjectivesWe have utilized mice with a disruption of the "leukocyte-type" 12-lipoxygenase gene (12-LO… CONTINUE READING
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