Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy.

@article{Nachman1998AugmentedPT,
  title={Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy.},
  author={James B. Nachman and Harland N. Sather and Martha G. Sensel and Michael e. Trigg and Joel M Cherlow and John Nicholas Lukens and Laura Wolff and Fatih M. Uckun and Paul S. Gaynon},
  journal={The New England journal of medicine},
  year={1998},
  volume={338 23},
  pages={1663-71}
}
BACKGROUND Children with high-risk acute lymphoblastic leukemia (ALL) who have a slow response to initial chemotherapy (more than 25 percent blasts in the bone marrow on day 7) have a poor outcome despite intensive therapy. We conducted a randomized trial in which such patients were treated with either an augmented intensive regimen of post-induction chemotherapy or a standard regimen of intensive post-induction chemotherapy. METHODS Between January 1991 and June 1995, 311 children with newly… CONTINUE READING
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Prednisone good response ( PGR ) identifies a subset of t ( 9 ; 22 ) childhood acute lymphoblastic leukemia ( ALL ) at lower risk for early leukemia relapse

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Prednisone good response (PGR) identifies a subset of t(9;22) childhood acute lymphoblastic leukemia (ALL) at lower risk for early leukemia relapse. Blood 1997;90:Suppl 1:560a-560a

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