Augmented interleukin-1beta-induced depression of locomotor activity in cholestatic rats.

@article{Swain1998AugmentedID,
  title={Augmented interleukin-1beta-induced depression of locomotor activity in cholestatic rats.},
  author={Mark Gordon Swain and Paul L. Beck and Kevin Rioux and Tai Le},
  journal={Hepatology},
  year={1998},
  volume={28 6},
  pages={1561-5}
}
"Sickness behaviors" such as lethargy, fatigue, and malaise occur commonly in patients with cholestatic liver diseases and contribute significantly to the morbidity associated with these diseases. However, the cause of these symptoms is unknown. Interleukin-1beta (IL-1beta) released within the brain has been implicated in the genesis of a number of "sickness behaviors," including malaise and lethargy. Therefore, we investigated whether experimental cholestatic liver disease caused by bile duct… CONTINUE READING