Augmented interleukin-18 production by peripheral blood monocytes in patients with minimal-change nephrotic syndrome.

@article{Matsumoto2001AugmentedIP,
  title={Augmented interleukin-18 production by peripheral blood monocytes in patients with minimal-change nephrotic syndrome.},
  author={Koichi Matsumoto and Katsuo Kanmatsuse},
  journal={American journal of nephrology},
  year={2001},
  volume={21 1},
  pages={20-7}
}
BACKGROUND/AIM The etiology of minimal-change nephrotic syndrome (MCNS) is poorly understood. It has been proposed that cell-mediated immunity and T-cell activation are key features of this glomerular disease. Interleukin (IL)-18, a novel interferon-gamma-stimulating factor, may act as an important effector molecule involved in various immune responses. To our knowledge, very little is known about the involvement of IL-18 in NCNS. The aim here was to define further the involvement of IL-18 in… CONTINUE READING

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