Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction.

@article{Miyasaka1988AugmentedIP,
  title={Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction.},
  author={Nobuyuki Miyasaka and Katsuaki Sato and Masamichi Goto and Minoru Sasano and M Natsuyama and Keiichi Inoue and Katsuhiro Nishioka},
  journal={Arthritis and rheumatism},
  year={1988},
  volume={31 4},
  pages={480-6}
}
Potent interleukin-1 (IL-1) activity was detected in culture supernatants from synovium, obtained by arthroscopy, from rheumatoid arthritis (RA) patients but not from non-RA patients. Production of IL-1 by RA synovium correlated well with findings of inflammation on arthroscopy and HLA-DR expression in immunohistochemical staining. Furthermore, there was a positive correlation between IL-1 production from RA synovium and joint changes detected on roentgenograms. These findings strongly suggest… CONTINUE READING