Augmented humoral and anaphylactic responses in FcγRII-deficient mice

@article{Takai1996AugmentedHA,
  title={Augmented humoral and anaphylactic responses in Fc$\gamma$RII-deficient mice},
  author={Toshiyuki Takai and Masao Ono and Masaki Hikida and Hitoshi Ohmori and Jeffrey V. Ravetch},
  journal={Nature},
  year={1996},
  volume={379},
  pages={346-349}
}
DESPITE its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immuno-globulin-G receptor, FcγRII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antibody production1–6. We now report that FcγRII-deficient animals display elevated immunoglobulin levels in response to both thymus-dependent and thymus-independent antigens. Additionally… 
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