Augmented humoral and anaphylactic responses in FcγRII-deficient mice
@article{Takai1996AugmentedHA, title={Augmented humoral and anaphylactic responses in Fc$\gamma$RII-deficient mice}, author={Toshiyuki Takai and Masao Ono and Masaki Hikida and Hitoshi Ohmori and Jeffrey V. Ravetch}, journal={Nature}, year={1996}, volume={379}, pages={346-349} }
DESPITE its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immuno-globulin-G receptor, FcγRII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antibody production1–6. We now report that FcγRII-deficient animals display elevated immunoglobulin levels in response to both thymus-dependent and thymus-independent antigens. Additionally…
784 Citations
Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice
- Biology, Medicine
- 1996
Regulation of murine hypersensitive responses by Fc receptors
- Biology
- 1998
Elucidation of the detailed mechanisms of negative regulatory signaling in the inflammatory effector cells by FcγRIIb as well as several groups of potent inhibitory molecules expressed on such cells should be valuable in the development of novel therapeutic procedures for allergic disorders.
Increased Severity of Local and Systemic Anaphylactic Reactions in Gp49b1-Deficient Mice
- Biology, MedicineThe Journal of experimental medicine
- 2001
The results indicate that gp49B1 innately dampens adaptive immediate hypersensitivity responses by suppressing mast cell activation in vivo, and provides a new concept and target for regulation of allergic disease susceptibility and severity.
Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice.
- Biology, MedicineThe Journal of clinical investigation
- 2006
It is shown that the development of a full-blown antibody-dependent autoimmune disease requires C5a--produced by and acting on FcgammaR--and may suggest therapeutic benefits of C5 and/or C5 a/C5aR blockade in AIHA and other diseases closely related to type II autoimmune injury.
IgG2a-Mediated Enhancement of Antibody and T Cell Responses and Its Relation to Inhibitory and Activating Fcγ Receptors1
- BiologyThe Journal of Immunology
- 2004
The presented data are compatible with the hypothesis that the mechanism behind IgG2a-mediated up-regulation of Ab responses involves increased Ag presentation to CD4+ T cells by FcγR+ APCs, and illustrate the intricate immunoregulatory role of IgG Abs.
Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG
- Biology, MedicineThe Journal of experimental medicine
- 1999
In addition to modulating IgG-triggered hypersensitivity responses, FcγRII and III on mast cells are potent regulators of IgE-mediated responses and reveal the existence of a regulatory pathway for IgE triggering of effector cells through IgG Fc receptors that could contribute to the etiology of the atopic response.
Lyn Is Essential for Fcγ Receptor III–Mediated Systemic Anaphylaxis but Not for the Arthus Reaction
- Biology, MedicineThe Journal of experimental medicine
- 2001
In insight into distinct signaling mechanisms in mast cells underlying the development of diverse pathologies as well as a therapeutic potential for selective treatment of allergic disorders, Lyn is not involved in the onset of the IgG-mediated, FcγRIII-dependent late phase responses of mast cells.
A Restricted Role for FcγR in the Regulation of Adaptive Immunity
- Biology, MedicineThe Journal of Immunology
- 2018
It is concluded that FcγRs are downstream IgG effector molecules with a restricted role in the ontogeny and maintenance of the immune system, as well as the regulation of adaptive immunity.
References
SHOWING 1-10 OF 17 REFERENCES
Cross-linking of IgG receptors inhibits membrane immunoglobulin- stimulated calcium influx in B lymphocytes
- BiologyThe Journal of cell biology
- 1993
The data show that Fc gamma RII does not mediate an overall inhibition of mIg signaling but specifically affects transmembrane Ca2+ influx without affecting the release of Ca2- from intracellular stores.
Cross-linking of B lymphocyte Fc gamma receptors and membrane immunoglobulin inhibits anti-immunoglobulin-induced blastogenesis.
- BiologyJournal of immunology
- 1984
It appears that the simultaneous binding of membrane IgM (or IgD) and Fc gamma R by whole anti-Ig antibodies prevents this early event in membrane Ig-induced B cell activation.
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade.
- Biology, MedicineScience
- 1994
The results suggest that immune complex-triggered inflammation is initiated by cell bound Fc receptors and is then amplified by cellular mediators and activated complement, redefine the inflammatory cascade and may offer other approaches for the study and treatment of immunological injury.
Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors.
- BiologyThe Journal of clinical investigation
- 1995
It is reported here that IgE-induced release of mediator and cytokine can be inhibited by cross-linking Fc epsilon RI to low-affinity IgG receptors (Fc gamma RII) which are constitutively expressed on mast cells and basophils which are of potential interest in mast cell physiology and in allergic pathology.
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling
- BiologyThe Journal of experimental medicine
- 1995
A role for PTP1C in regulating the tyrosine phosphorylation state of the resting BCR complex components is suggested, supported by the observation that PTP 1C specifically induces dephosphorylation of a 35-kD BCR-associated protein likely representing Ig-alpha.
The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation.
- BiologyImmunity
- 1995
Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors
- Biology, MedicineThe Journal of experimental medicine
- 1985
Results indicate that crosslinkage of Fc and surface Ig receptors on B cells inhibits inositol phospholipid breakdown (but not Ca2+ flux) resulting from ligation of the antigen receptors.
The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor.
- BiologyJournal of immunology
- 1987
A biochemical basis for mIg- and Fc gamma R-mediated activation and regulation intrinsic to the B cell is outlined, and the advantages of indo-1 over quin2 for fluorescent measurement of [Ca2+]i in small cells are demonstrated.