Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.

@article{Saito1989AugmentedEO,
  title={Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.},
  author={Yoshinobu Saito and Kazuwa Nakao and Hidenori Arai and Kyohei Nishimura and Kenji Okumura and Kouji Obata and Genzou Takemura and Hisayoshi Fujiwara and A Sugawara and Takashi Yamada},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={83 1},
  pages={
          298-305
        }
}
To elucidate the expression of the atrial natriuretic polypeptide (ANP) gene in the ventricle of the human failing heart, we have measured ANP and ANP messenger RNA (ANPmRNA) levels in left ventricular aneurysm obtained at operation, biopsy specimens of left ventricles from dilated cardiomyopathy (DCM) and autopsy samples of old myocardial infarction (OMI) and DCM hearts, and compared the levels with those in the normal ventricle. The ANP level (mean +/- SE) was 17.5 +/- 6.9 ng/g in the normal… CONTINUE READING

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