Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs.

@article{Chatzizisis2011AugmentedEA,
  title={Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs.},
  author={Yiannis S. Chatzizisis and Aaron B. Baker and Galina K Sukhova and Konstantinos C. Koskinas and Michail I. Papafaklis and Roy Beigel and Michael Jonas and Ahmet U. Coskun and Benjamin V. Stone and Charles Maynard and G P Shi and P. Scott Libby and Charles L. Feldman and Elazer R. Edelman and Peter H. Stone},
  journal={Circulation},
  year={2011},
  volume={123 6},
  pages={621-30}
}
Background- The molecular mechanisms that determine the localized formation of thin-capped atheromata in the coronary arteries remain unknown. This study tested the hypothesis that low endothelial shear stress augments the expression of matrix-degrading proteases and thereby promotes the formation of thin-capped atheromata. Methods and Results- Intravascular ultrasound-based, geometrically correct 3-dimensional reconstruction of the coronary arteries of 12 swine was performed in vivo 23 weeks… CONTINUE READING

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