Augmented brain 5‐HT crosses the blood–brain barrier through the 5‐HT transporter in rat

@article{Nakatani2008AugmentedB5,
  title={Augmented brain 5‐HT crosses the blood–brain barrier through the 5‐HT transporter in rat},
  author={Yasushi Nakatani and Ikuko Sato-Suzuki and Naohisa Tsujino and Akane Nakasato and Yoshinari Seki and Masaki Fumoto and Hideho Arita},
  journal={European Journal of Neuroscience},
  year={2008},
  volume={27}
}
The present study re‐evaluated an existing notion that serotonin (5‐hydroxytryptamine; 5‐HT) could not cross the brain to the circulating blood via the blood–brain barrier (BBB). To elevate brain 5‐HT alone, 5‐hydroxytryptophan (5‐HTP; 30–75 mg/kg) was administrated intravenously to anaesthetized rats that had undergone gastrointestinal and kidney resections along with liver inactivation (organs contributing to increasing blood 5‐HT after 5‐HTP administration). A microdialysis method and HPLC… Expand
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