Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin

@article{Yuvaraj2007AugmentedAS,
  title={Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin},
  author={S. Yuvaraj and V. Premkumar and K. Vijayasarathy and Sitthu Govindaswamy Dinakaran Gangadaran and P. Sachdanandam},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2007},
  volume={61},
  pages={933-941}
}
BackgroundReactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide (H2O2), hydroxyl radical have been implicated in pathogenesis of various diseases including cancer and metastasis. Tamoxifen (TAM) is a non-steroidal anti-estrogen drug most widely used as an adjuvant hormonal therapy in breast cancer. TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress and hypertriglycerdemia. Coenzyme Q10 (CoQ10), Niacin and Riboflavin are well-known… Expand
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