Augmented anti-angiogenesis activity of polysulfated heparin-endostatin and polyethylene glycol-endostatin in alkali burn-induced corneal ulcers in rabbits.

Abstract

Endostatin (ES) is an endogenous angiogenesis inhibitor that has the ability to inhibit tumor growth and metastasis. However, its clinical application is limited by a number of disadvantages, such as poor stability, short half-life and the requirement of high doses to maintain its efficacy. The chemical modification on ES may offer a solution to these… (More)

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@article{Li2015AugmentedAA, title={Augmented anti-angiogenesis activity of polysulfated heparin-endostatin and polyethylene glycol-endostatin in alkali burn-induced corneal ulcers in rabbits.}, author={Zhao-na Li and Zhong-Fang Yuan and Guo-Ying Mu and Ming Hu and Li-jun Cao and Ya-Li Zhang and Ming-Xu Ge}, journal={Experimental and therapeutic medicine}, year={2015}, volume={10 3}, pages={889-894} }