Augmented analgesic effects of enkephalinase inhibitors combined with transcranial electrostimulation.

@article{Malin1989AugmentedAE,
  title={Augmented analgesic effects of enkephalinase inhibitors combined with transcranial electrostimulation.},
  author={David H. Malin and J. Ronald Lake and Raymond F. Hamilton and M H Skolnick},
  journal={Life sciences},
  year={1989},
  volume={44 19},
  pages={
          1371-6
        }
}
The analgesic effects of very low current transcranial electrostimulation are naloxone-reversible and thus presumably mediated by endogenous opioid activity. The present experiments indicate that blocking enkephalinase activity by i.c.v. thiorphan or i.p. acetorphan results in an increased analgesic effect of electrostimulation as measured by the 50 degrees… CONTINUE READING