Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension.

@article{Shimokubo1995AugmentedAC,
  title={Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension.},
  author={Toru Shimokubo and Junichiro Sakata and Kazuo Kitamura and Kenji Kangawa and Hisayuki Matsuo and Tanenao Eto},
  journal={Life sciences},
  year={1995},
  volume={57 19},
  pages={1771-9}
}
Adrenomedullin is a strong vasorelaxing peptide discovered in pheochromocytoma tissue. Monocrotaline, a pyrrolizidine alkaloid derived from Crotalaria spectabilis, is known to cause pulmonary hypertension. To test the hypothesis that adrenomedullin plays a role similar to that of atrial natriuretic peptide or brain natriuretic peptide in modulating right ventricular responses to pulmonary hypertension, we have compared concentrations of immunoreactive rat adrenomedullin and adrenomedullin… CONTINUE READING