Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats.

@article{Stepp2002AugmentedAV,
  title={Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats.},
  author={David W. Stepp and Jefferson C Frisbee},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 3},
  pages={H816-20}
}
This study examined skeletal muscle microvessel reactivity to constrictor stimuli in obese (OZR) versus lean Zucker rats (LZR). Gracilis arteries from both rat groups were isolated, cannulated with glass micropipettes, and viewed via television microscopy. Changes in vessel diameter were measured with a video micrometer. Arterial constriction to norepinephrine was elevated in OZR versus LZR, although vasoconstrictor reactivity to endothelin and angiotensin II was unaltered. Differences in… CONTINUE READING

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Relative contributions of cyclooxygenase- and cytochrome P450 -hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries

Frisbee Roman JCRJ, UM Krishna, Falck, JH Lombard
J Vasc Res • 2001
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