Augmented a-Adrenergic Constriction of Atherosclerotic Human Coronary Arteries

  title={Augmented a-Adrenergic Constriction of Atherosclerotic Human Coronary Arteries},
  author={D. Baumgart and Michael Haude and G. Goerge and Fengqi Liu and Junbo Ge and Claudia Gro\sse-Eggebrecht and Raimund Erbel and Gerd Heusch},
Background—Although adrenergic activation plays a major role in the initiation of experimental myocardial ischemia, the significance ofa-adrenergic coronary constriction in humans has been questioned. The present study assessed the impact of selectivea-adrenergic receptor activation in patients with normal or atherosclerotic coronary arteries. Methods and Results —In 39 patients, coronary blood flow (CBF, mL/min) was determined from combined angiography and Doppler measurements. In 8 patients… CONTINUE READING
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