Augmented O‐GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast‐induced acute kidney injury in rats

@article{Hu2017AugmentedOS,
  title={Augmented O‐GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast‐induced acute kidney injury in rats},
  author={Jiachang Hu and Rongyi Chen and Ping Jia and Yi Fang and Tongqiang Liu and Nana Song and Xialian Xu and Jun Ji and Xiaoqiang Ding},
  journal={Free Radical Biology and Medicine},
  year={2017},
  volume={103},
  pages={121–132}
}
ABSTRACT Contrast‐induced acute kidney injury (CI‐AKI) is an iatrogenic renal injury and associated with substantial morbidity and mortality in susceptible individuals. Despite extensive study of a variety of agents for renal protection, limited strategies have been shown to be effective in the reduction of CI‐AKI. O‐linked &bgr;‐N‐acetylglucosamine (O‐GlcNAc) is a post‐translational regulatory modification of intracellular proteins and governs the function of numerous proteins, both cytosolic… Expand
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