Augmented Intestinal Trefoil Factor (TFF3) and Loss of pS2 (TFF1) Expression Precedes Metaplastic Differentiation of Gastric Epithelium

@article{Taupin2001AugmentedIT,
  title={Augmented Intestinal Trefoil Factor (TFF3) and Loss of pS2 (TFF1) Expression Precedes Metaplastic Differentiation of Gastric Epithelium},
  author={Douglas R. Taupin and John Pedersen and Mary Familari and Greg Cook and Neville Yeomans and Andrew S. Giraud},
  journal={Laboratory Investigation},
  year={2001},
  volume={81},
  pages={397-408}
}
The trefoil peptides spasmolytic polypeptide (SP), intestinal trefoil factor (ITF), and pS2 show lineage-specific expression in the normal gut and are strongly induced after mucosal injury. We assessed the relationship between this induction and the development of the regenerative epithelial lineage over time in the rat stomach and verified these observations in the metaplastic and dysplastic human stomach. Antral or colonic ulcers were induced in Wistar rats by application of serosal acetic… CONTINUE READING

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