Augmented HIV vaccine trial design for estimating reduction in infectiousness and protective efficacy.

  title={Augmented HIV vaccine trial design for estimating reduction in infectiousness and protective efficacy.},
  author={Susmita Datta and M. Elizabeth Halloran and Ira M. Longini},
  journal={Statistics in medicine},
  volume={17 2},
It is important to design HIV vaccine trials to estimate the efficacy of a vaccine in reducing infectiousness in addition to the protective efficacy. Currently planned phase III HIV vaccine field trials in which at-risk individuals are randomized and followed over time do not permit estimation or testing of the vaccine's effect on reducing infectiousness of vaccinees who become infected. We suggest an augmentation of these field trials that recruits steady sexual partners of the primary… CONTINUE READING

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