Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice.

@article{Livermore2015Augmented5S,
  title={Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice.},
  author={Simon Livermore and Jie Pan and Herman Yeger and Peter Ratcliffe and Tammie Bishop and Ernest Cutz},
  journal={Advances in experimental medicine and biology},
  year={2015},
  volume={860},
  pages={309-13}
}
Sustained exposure to low oxygen concentration leads to profound changes in gene expression to restore oxygen homeostasis. Hypoxia-inducible factors (HIFs) comprise a group of transcription factors which accumulate under hypoxia and contribute to the complex changes in gene expression. Under normoxic conditions HIFs are degraded by prolyl-hydroxylases (PHD), however during hypoxia this degradation is inhibited causing HIF accumulation and subsequent changes in gene expression. Pulmonary… CONTINUE READING