Augmented 18 F-FDG Uptake in Activated Monocytes Occurs During the Priming Process and Involves Tyrosine Kinases and Protein Kinase C

@inproceedings{Paik2003Augmented1F,
  title={Augmented 18 F-FDG Uptake in Activated Monocytes Occurs During the Priming Process and Involves Tyrosine Kinases and Protein Kinase C},
  author={J J Paik and K Lee and Yearn Seong Choe and Yong Soo Choi and B. T. Kim},
  year={2003}
}
Activated monocytes with a high 18F-FDG accumulation can affect the results of clinical PET studies. To better understand the mechanisms regulating monocytic 18F-FDG uptake, we investigated the effect of priming and respiratory-burst generation and further evaluated the role of potential protein kinase pathways. Methods: Purified human monocytes were primed with interferon(IFN), and respiratory burst was generated by stimulation of primed cells with phorbol-12-myristate-13-acetate (PMA). Oxygen… CONTINUE READING

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