Augmentative effects of L-cysteine and methylmethionine sulfonium chloride on mucin secretion in rabbit gastric mucous cells.

@article{Watanabe2000AugmentativeEO,
  title={Augmentative effects of L-cysteine and methylmethionine sulfonium chloride on mucin secretion in rabbit gastric mucous cells.},
  author={Takashi Watanabe and Shyuichi Ohara and Shinobu Miyazawa and Katsunori Saigenji and Kyoko Hotta},
  journal={Journal of gastroenterology and hepatology},
  year={2000},
  volume={15 1},
  pages={45-52}
}
BACKGROUND Our previous study showed that L-cysteine (Cys) and methylmethionine sulfonium chloride (MMSC) inhibited ethanol-induced gastric mucosal damage and increased the amount of surface mucin in rats. This study examined whether Cys and MMSC augmented mucin secretion and changed distribution of mucin vesicles ultrastructurally in mucous cells by using primary cultured mucous cells from rabbit glandular stomach. Changes in intracellular cyclic adenosine 3',5'-monophosphate (cAMP) and in… CONTINUE READING