Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure.

@article{Li1993AugmentationOT,
  title={Augmentation of tumour delivery of macromolecular drugs with reduced bone marrow delivery by elevating blood pressure.},
  author={Chao Jun Li and Yoshinori Miyamoto and Yoji Kojima and Hiroshi Maeda},
  journal={British Journal of Cancer},
  year={1993},
  volume={67},
  pages={975 - 980}
}
Effects of angiotensin II (AT-II)-induced hypertension on the distribution of macromolecules to Walker carcinoma and to bone marrow of SMANCS [poly(styrene-co-maleic-acid)-neocarzinostatin conjugate] were investigated in rats. AT-II-induced hypertension from about 100 to 150 mmHg significantly increased the accumulation of the macromolecular drug SMANCS and 51Cr-labelled bovine serum albumin ([51Cr]BSA), representatives of macromolecular drugs, in tumour tissue. At 1 h after i.v. administration… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Tailor - making of protein drugs by polymer conjugation for tumor targeting : a brief review on smancs

  • H. MAEDA, T. MATSUMOTO, T. KONNO, K. IWAI, M. UEDA
  • J . Protein Chem .
  • 1984
Highly Influential
5 Excerpts

Tailor-making of protein drugs by polymer conjugation for tumor targeting

  • H. MAEDA, T. MATSUMOTO, T. KONNO, K. IWAI, M. UEDA
  • 1984
Highly Influential
5 Excerpts

Kinin-generating cascade

  • T. KONNO, H. MAEDA
  • 1991

Similar Papers

Loading similar papers…