Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL‐21
@article{Takeda2018AugmentationOT, title={Augmentation of the expression of the eotaxin receptor on duodenal neutrophils by IL‐21}, author={Yuji Takeda and Tomoyuki Kato and Nobuhito Nemoto and Akemi Araki and Mohammad Yeashin Gazi and Hidetoshi Nara and Hironobu Asao}, journal={Cytokine}, year={2018}, volume={110}, pages={194–203} }
4 Citations
Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue.
- BiologyFree radical biology & medicine
- 2020
Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.
- Medicine, BiologyThe Journal of nutritional biochemistry
- 2021
Heterozygous SOD1 deficiency in mice with an NZW background causes male infertility and an aberrant immune phenotype
- BiologyFree radical research
- 2019
The collective results suggest that the oxidative stress caused by an SOD1 haploinsufficiency exerts deleterious effects on the testis, either directly on spermatogenic cells or via the destabilisation of the autoimmune response in Sod1+/−/NZW mice.
References
SHOWING 1-10 OF 48 REFERENCES
IL-21 Induces Inhibitor of Differentiation 2 and Leads to Complete Abrogation of Anaphylaxis in Mice1
- Biology, MedicineThe Journal of Immunology
- 2007
The present study strongly suggests that IL-21 is capable of regulating systemic allergic reactions by inducing the transcriptional regulator Id2, and the cytokine may be useful for clinical intervention for allergic diseases including anaphylaxis.
A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy.
- Medicine, BiologyProceedings of the National Academy of Sciences of the United States of America
- 2000
It is established that the accumulation of gastrointestinal eosinophils is antigen induced, can occur independent of IL-5, and provides a molecular mechanism to explain the dichotomy between peripheral blood and tissue eOSinophilia.
Human Peripheral Neutrophils Express Functional IL-21 Receptors
- Biology, MedicineInflammation
- 2014
It is shown that human neutrophils in peripheral blood express functional IL-21 receptors (IL-21Rs), and whole blood flow cytometric assays indicated that IL- 21 has the potential to enhance the neutrophil functions.
Regulation of gut inflammation and th17 cell response by interleukin-21.
- Biology, MedicineGastroenterology
- 2008
Results indicate that IL-21 is a critical regulator of inflammation and Th17 cell responses in the gut, as shown in mice induced with dextran sulfate sodium- and trinitrobenzene sulfonic acid-relapsing colitis.
The pattern of GPI‐80 expression is a useful marker for unusual myeloid maturation in peripheral blood
- Biology, MedicineClinical and experimental immunology
- 2016
It is proposed that the pattern of GPI‐80 expression in neutrophil or monocyte populations is a simple and useful marker for unusual differentiation, which is related to MDSC functions.
Neutrophils in local and systemic antibody‐dependent inflammatory and anaphylactic reactions
- Biology, MedicineJournal of leukocyte biology
- 2013
This review focuses on the engagement, activation, and responses of neutrophils to antibody ICs, inside of tissues or in the vasculature.
Eotaxin is required for the baseline level of tissue eosinophils.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 1998
It is demonstrated that eotaxin is a fundamental regulator of the physiological trafficking of eosinophils during healthy states and involvement in the baseline trafficking of leukocytes into nonhematopoietic tissue should now be considered.
The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 2002
It is shown that CCR3 is important for the basal trafficking of eosinophils to the intestinal mucosa but not the lung, underscoring a more complex role for C CR3 in allergic disease than was anticipated.
Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression1
- BiologyThe Journal of Immunology
- 2000
The generation of tissue eosinophilia is governed in part by chemokines; initial investigation has identified three chemokines in the human genome with eosinophil selectivity, referred to as…
A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.
- Biology, MedicineThe Journal of clinical investigation
- 2012
It is demonstrated that suppression of T cell function can be accomplished by a subset of human neutrophils that can be systemically induced in response to acute inflammation.