Augmentation of superoxide dismutase and catalase activity in alveolar type II cells.

@article{Walther1991AugmentationOS,
  title={Augmentation of superoxide dismutase and catalase activity in alveolar type II cells.},
  author={Frans J Walther and Andrew B. Wade and David John Warburton and Henry J Forman},
  journal={American journal of respiratory cell and molecular biology},
  year={1991},
  volume={4 4},
  pages={
          364-8
        }
}
This study tested whether adducts formed by covalent linkage of superoxide dismutase (SOD) or catalase to polyethylene glycol (PEG) could augment SOD and catalase activity in alveolar type II cells and document enhanced resistance to oxidant damage. Alveolar type II cells were isolated from adult, pathogen-free rats. Antioxidant enzymes were added to the medium of cell cultures in various concentrations for periods up to 48 h. Incubation with 500 to 3,000 U of PEG-SOD or 10,000 to 40,000 U of… CONTINUE READING
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