Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.

@article{Fishbein2014AugmentationOP,
  title={Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.},
  author={Ianai Fishbein and Y M Kuo and Benoit I Giasson and Robert L Nussbaum},
  journal={Brain : a journal of neurology},
  year={2014},
  volume={137 Pt 12},
  pages={3235-47}
}
The involvement of the protein α-synuclein (SNCA) in the pathogenesis of Parkinson's disease is strongly supported by the facts that (i) missense and copy number mutations in the SNCA gene can cause inherited Parkinson's disease; and (ii) Lewy bodies in sporadic Parkinson's disease are largely composed of aggregated SNCA. Unaffected heterozygous carriers of Gaucher disease mutations have an increased risk for Parkinson's disease. As mutations in the GBA gene encoding glucocerebrosidase (GBA… CONTINUE READING
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