Augmentation of peritoneal dialysis clearance with procaine.

@article{Brborowicz1984AugmentationOP,
  title={Augmentation of peritoneal dialysis clearance with procaine.},
  author={Andrzej Bręborowicz and Jan Knapowski},
  journal={Kidney international},
  year={1984},
  volume={26 4},
  pages={
          392-6
        }
}
Local anesthetic procaine in a 0.25% concentration was used as the adjunct to the dialysis fluid during peritoneal dialysis in rabbits. Procaine increased peritoneal clearance of urea (2.213 +/- 0.187 ml/min to 3.544 +/- 0.41 ml/min) and inulin (0.528 +/- 0.079 ml/min to 0.852 +/- 0.213 ml/min). Effect of the drug persisted, despite its lack, during the following cycles. Procaine influenced transmesothelial transfer of urea and inulin in vitro. The effect of the drug was biphasic. During the… 
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References

SHOWING 1-10 OF 22 REFERENCES
Enhancement of peritoneal dialysis clearance with docusate sodium.
TLDR
The results of this study indicate that DSS has a significant effect on clearance of both creatinine and urea, and no animals showed signs of toxicity from DSS.
Effect of dialysate volume on peritoneal dialysis kinetics.
TLDR
The data indicate that slower urea equilibration with larger dialysate volumes is due to changes in volume/surface area relationships, and patients susceptible to cardiopulmonary complications may be dialyzed without loss of efficiency by infusing 1 liter every 30 min instead of the usual 2 liters every 60 min.
Effect of dialysate temperature and flow rate on peritoneal clearance.
TLDR
The most efficient method of dialysis with commercially available equipment is a repeated 2-liter exchange of dialysate at 37 C with no pause between inflow and outflow.
Peritoneal ultrafiltration dialysis: enhanced urea transfer using hypertonic peritoneal dialysis fluid.
  • L. Henderson
  • Medicine, Biology
    The Journal of clinical investigation
  • 1966
TLDR
Solutions hypertonic to plasma enhance the transfer ofurea across the peritoneal membrane and result inamarkedly improvedperitoneal clearance ofthissolute, and the datasuggests the probable mechanism responsible for this effect.
Peritoneal dialysis today: a new look.
TLDR
It is suggested that perhaps as many as 20–25% of patients in need of dialysis should preferentially receive peritoneal dialysis treatment.
Urokinase for the treatment of acute pulmonary thromboembolism.
TLDR
Surgical indications for the treatment of pulmonary thromboembolism are modified to consider for urokinase therapy all patients with massive bilateral pulmonary emboli in shock and those in whom inferior caval ligation is usually recommended for the prevention of further embolization.
Cytoplasmic regulation of tight-junction permeability: effect of plant cytokinins.
TLDR
P permeability of the tight junction of Necturus gallbladder is subject to rapid reversible modulation, possibly under cytoskeletal control, to suggest that the significance of the "leaky" tight junction might be understood better if cells of the epithelial monolayer possessed mechanisms to regulate molecular flow through the junction.
Effects of local anesthetics on cell morphology and membrane-associated cytoskeletal organization in BALB/3T3 cells
TLDR
The relationship of the findings on local anesthetic-induced changes in cellular cytoskeletal systems is discussed in relation to previous proposals on plasma membrane organization and control of cell surface receptor topography and mobility.
...
...