Augmentation of olanzapine in treatment-resistant schizophrenia.

  title={Augmentation of olanzapine in treatment-resistant schizophrenia.},
  author={Mathias Zink},
  journal={Journal of psychiatry & neuroscience : JPN},
  volume={30 6},
  • Mathias Zink
  • Published 2005 in Journal of psychiatry & neuroscience : JPN
OBJECTIVE Up to 40% of patients with schizophrenic psychoses have symptoms that are resistant to monotherapy with antipsychotic drugs. In consequence, combinations of drugs are often used, especially based on the antipsychotic agents clozapine and olanzapine because of their broad receptor-interaction profile. The aim of this review was to provide a critical overview of the published results of olanzapine augmentation. METHODS A systematic database search was performed of MEDLINE and BIOSIS… CONTINUE READING