Augmentation of monocyte-mediated antibody-dependent cellular cytotoxicity by protein synthesis inhibitors: evidence for an endogenous regulatory mechanism.

Abstract

Protein synthesis inhibitors, cycloheximide and puromycin, were used in cytotoxic assays employing human peripheral blood monocytes as effectors and sheep erythrocytes as target cells. ADCC could be initiated and could also achieve its full lytic activity in the absence of new protein synthesis. Furthermore, an augmentation of ADCC was observed in the… (More)

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@article{Tripathi1991AugmentationOM, title={Augmentation of monocyte-mediated antibody-dependent cellular cytotoxicity by protein synthesis inhibitors: evidence for an endogenous regulatory mechanism.}, author={A. K. Tripathi and Michael Taplits and Joseph Puri and Timothy M. Hoffman}, journal={Cellular immunology}, year={1991}, volume={134 2}, pages={491-504} }