Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene.

@article{Factor1998AugmentationOL,
  title={Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene.},
  author={Phillip Factor and Fernando Pe{\~n}afiel Sald{\'i}as and Karen Ridge and Vidas Gr. Dumasius and Joseph Zabner and Howard A. Jaffe and Gustavo Blanco and Matthew Barnard and Robert W. Mercer and Raymond Perrin and Jacob I Sznajder},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 7},
  pages={1421-30}
}
Previous studies have suggested that alveolar Na,K-ATPases play an important role in active Na+ transport and lung edema clearance. We reasoned that overexpression of Na,K-ATPase subunit genes could increase Na,K-ATPase function in lung epithelial cells and edema clearance in rat lungs. To test this hypothesis we produced replication deficient human type 5 adenoviruses containing cDNAs for the rat alpha1 and beta1 Na,K-ATPase subunits (adMRCMValpha1 and adMRCMVbeta1, respectively). As compared… CONTINUE READING

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