Augmentation of lithium's behavioral effect by inositol uptake inhibitors

@article{Einat1998AugmentationOL,
  title={Augmentation of lithium's behavioral effect by inositol uptake inhibitors},
  author={Haim Einat and Ora Kofman and O. Itkin and R. J. Lewitan and Robert H. Belmaker},
  journal={Journal of Neural Transmission},
  year={1998},
  volume={105},
  pages={31-38}
}
Summary. Lithium inhibits the enzyme inositol monophosphatase and thus obstructs the enzymatic degradation of inositol triphosphate (IP3) to inositol in the phosphate-phosphoinositide (PIP) cycle. This inhibition may result in reduced availability of the second messengers IP3 and DAG that are derivates of the PIP cycle, and this action is currently a leading hypothesis regarding lithium's therapeutic and prophylactic effect in affective disorders. Inositol is also available to the cell by… 
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It is suggested that the large, slowly exchanging compartment is largely membrane-associated and participating in signaling via the phosphatidylinositide second messenger system, whereas inositol functioning as an osmolyte is distributed in the cytosol and located in one or both of the compartments showing a faster release.
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TLDR
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TLDR
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TLDR
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TLDR
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