Augmentation of insulin-stimulated ANP release through tyrosine kinase and PI 3-kinase in diabetic rats.

Abstract

The aim of present study was to define the effects of insulin on atrial dynamics and ANP release and its modification in diabetic rats. An isolated perfused beating atrial model was used from control and diabetic rats. Insulin was perfused with and without an inhibitor for tyrosine kinase or phosphatidylinositol 3-kinase (PI 3-kinase). Insulin increased the… (More)

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