Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4+ T-cell clone reacting to TEL/AML1 fusion protein.

@article{Yun1999AugmentationOI,
  title={Augmentation of immune response by altered peptide ligands of the antigenic peptide in a human CD4+ T-cell clone reacting to TEL/AML1 fusion protein.},
  author={C W Yun and Satoru Senju and Hideaki Fujita and Yoshiro Tsuji and Atsushi Irie and Sayaka Matsushita and Yasuharu Nishimura},
  journal={Tissue antigens},
  year={1999},
  volume={54 2},
  pages={153-61}
}
The 12;21 chromosomal translocation occurs in leukemic cells from 20(30% of patients with B-lineage childhood acute lymphoblastic leukemia, the result being the TEL/AML1 fusion gene carrying a sequence different from TEL or AML1. Because the protein newly formed by TEL/ AML1 fusion is probably not tolerated by human immune system, the fusion region is a good candidate for tumor antigen expressed only in TEL/ AML1-positive leukemic cells. We established two human CD4+ alphabeta T-cell clones… CONTINUE READING

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